Evolution and Genetics

Improved Prime Editing System Enables Gene-Sized Edits in Human Cells at Therapeutic Levels

Improved Prime Editing System Enables Gene-Sized Edits in Human Cells at Therapeutic Levels

  • February 10, 2026
Source: Nature Biomedical Engineering | June 10, 2024 Background: Limits of Existing Gene-Editing T[...]
Continue Reading
The largest and most diverse study on recessive genetic changes in developmental disorders reveals that over 80% of cases caused by recessive variants are linked to known genes. Researchers analyzed data from nearly 30,000 families and found that a shift in focus from gene discovery to interpreting changes in known genes could double diagnosis rates. • The study highlights the importance of genetic background in diagnosis and suggests that some patients may have multiple contributing genetic factors. These findings could lead to more personalized and accurate diagnoses for families affected by developmental disorders. • They include Joubert syndrome, Bardet-Biedl syndrome and TaySachs disease. Until now, overall quantification of these recessive genetic causes across diverse populations has not been done. • The team found the number of patients affected by recessive genetic variants varied greatly between different ancestry groups, ranging from two to 19 per cent of cases. This variation is strongly linked to the prevalence of unions between close relatives – consanguinity – in these groups.

The largest and most diverse study on recessive genetic changes in developmental disorders reveals that over 80% of cases caused by recessive variants are linked to known genes. Researchers analyzed data from nearly 30,000 families and found that a shift in focus from gene discovery to interpreting changes in known genes could double diagnosis rates. • The study highlights the importance of genetic background in diagnosis and suggests that some patients may have multiple contributing genetic factors. These findings could lead to more personalized and accurate diagnoses for families affected by developmental disorders. • They include Joubert syndrome, Bardet-Biedl syndrome and TaySachs disease. Until now, overall quantification of these recessive genetic causes across diverse populations has not been done. • The team found the number of patients affected by recessive genetic variants varied greatly between different ancestry groups, ranging from two to 19 per cent of cases. This variation is strongly linked to the prevalence of unions between close relatives – consanguinity – in these groups.

  • February 07, 2026
Source: Nature Genetics | September 23, 2024 Context: The Power of Genetic Research in Developmenta[...]
Continue Reading
Where Modern Humans and Neanderthals Became One

Where Modern Humans and Neanderthals Became One

  • January 17, 2026
Source: Scientific Reports | September 03, 2024 The New Evidence Recent research published in Scie[...]
Continue Reading
Apes Understand the Reasons Behind Each Other’s Actions

Apes Understand the Reasons Behind Each Other’s Actions

  • January 13, 2026
Source: phys.org | September 18, 2024 Early Observations of Ape Communication The scientific study[...]
Continue Reading
Preventing Malaria Using Genetically Modified Malaria Parasites

Preventing Malaria Using Genetically Modified Malaria Parasites

  • January 08, 2026
Source: The Hindu | December 09, 2024 The Public Health Context Malaria remains a major global pub[...]
Continue Reading
Gene Therapy Restores Vision in Patients with Rare Genetic Disorder

Gene Therapy Restores Vision in Patients with Rare Genetic Disorder

  • December 30, 2025
Source: The Lancet | September 05, 2024 The Breakthrough Researchers have developed a gene therapy[...]
Continue Reading

Featured Posts

Categories