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UPSC MainsAnthropology Optional Paper I 2026 10 Marks Model Answer Available

Nuclear and Mitochondrial DNA: Distinguishing Features — 2026 Paper I

Question · 2026 · Paper I · 10 Marks

Distinguishing features of nuclear and mitochondrial DNA.

Model Answer

VAID ICS
Approach

  • Demand of Question: Compare nuclear DNA and mitochondrial DNA in structure, inheritance, recombination, copy number and anthropological utility.
  • Structuring the Response: Compact comparison → inheritance/recombination/copy number → ancestry and ancient-DNA uses → mtDNA limitation → conclusion.
  • Key Dimensions to Cover: Linear vs circular DNA, biparental vs maternal inheritance, recombination, high mtDNA copy number, genome-wide ancestry, maternal haplogroups.

 

Model Answer

Introduction: Humans possess a large nuclear genome and a small mitochondrial genome. Their different Answer structure and Flows and inheritance patterns give them different uses in biological anthropology and population genetics.

Feature Nuclear DNA Mitochondrial DNA
Location Nucleus; 23 chromosome pairs Mitochondria in cytoplasm
Answer structure and Flow Linear chromosomes; ~3.2 billion bp haploid genome Small circular molecule; ~16.6 kb
Genes Vast majority of human genes 37 genes—13 proteins, 22 tRNAs, 2 rRNAs
Inheritance Biparental for autosomes Predominantly maternal
Recombination Extensive during meiosis Generally treated as non-recombining for lineage studies
Copy number Usually two copies per autosomal locus in diploid cells Many molecules per cell
Variation Genome-wide ancestry/admixture Maternal haplogroups; heteroplasmy can occur

 

Anthropological significance:

  • Nuclear DNA samples ancestry across thousands of loci and is powerful for admixture, kinship, population history and selection.
  • mtDNA’s high copy number historically made it easier to recover from degraded bone, teeth or hair, giving it major importance in ancient-DNA and forensic studies.
  • Maternal inheritance permits reconstruction of maternal lineages.

However, mtDNA traces only one maternal genealogical pathway and should not be equated with the complete history of a population.

Conclusion: Modern molecular anthropology combines genome-wide nuclear DNA with mtDNA: nDNA provides broad biparental history, while mtDNA provides a high-copy maternal lineage record.

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